[Molecular genetic diagnosis of Wiskott-Aldrich syndrome].

  title={[Molecular genetic diagnosis of Wiskott-Aldrich syndrome].},
  author={Ulrike Orth and Walter Rosenkranz and Eberhard Schwinger and Wolfgang Holzgreve and Andreas Gal},
  journal={Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde},
  volume={141 9},
BACKGROUND/AIMS Wiskott-Aldrich syndrome is a severe X-linked recessive disorder of the hematopoietic system. The gene locus for Wiskott-Aldrich syndrome was mapped on the proximal short arm of the X chromosome by demonstrating close linkage to the loci DXS255 and TIMP. Carriers for Wiskott-Aldrich syndrome are asymptomatic and, hence, can not be identified clinically. METHODS For a better estimate of the carrier risk of female family members, an extended molecular genetic analysis has been… CONTINUE READING