• Corpus ID: 24249736

[Molecular cytogenetic study of an extra small chromosome].

  title={[Molecular cytogenetic study of an extra small chromosome].},
  author={S M Fu and H Fu and H. Xiao and X. Song and J Chen and C S Gao and H. Qiu and Z Y Cheng},
  journal={Yi chuan xue bao = Acta genetica Sinica},
  volume={19 4},
  • S. Fu, H. Fu, Z. Cheng
  • Published 1992
  • Biology, Medicine
  • Yi chuan xue bao = Acta genetica Sinica
An extra small chromosome was observed in a three-generation family. Eight members of this family were involved, but their phenotypes were normal. Molecular cytogenetic study was carried out, using cytogenetic methods and chromosome in situ hybridization with 3H-labelled rDNA probe. The results showed that this chromosome was from the short arm of chromosome of D/G group. The origin and genetic effects of this chromosome and fertility of the carriers were also discussed were also discussed… 
Novel generation of human satellite DNA-based artificial chromosomes in mammalian cells.
It is demonstrated that induced de novo chromosome formation is a reproducible and effective methodology in generating artificial chromosomes from predictable sequences of different mammalian species.