[Molecular cloning and expression of homeobox-containing genes during hard tissue development].

@article{Iimura1994MolecularCA,
  title={[Molecular cloning and expression of homeobox-containing genes during hard tissue development].},
  author={Tadahiro Iimura},
  journal={Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan},
  year={1994},
  volume={61 4},
  pages={
          590-604
        }
}
  • T. Iimura
  • Published 1 December 1994
  • Biology
  • Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan
Although much is known about the hormonal regulation of hard tissue development, much less is known about the nuclear regulatory molecules that affect the process. Homeobox-containing genes are thought to encode DNA-binding transcriptional factors which control the expression of other genes. In this study, molecular cloning of Msx homeobox-containing genes from a bovine odontoblast library and a human dental pulp-derived cells library was performed, and also the expression of mRNAs for Hox and… 
1 Citations
The canine homeobox gene MSX2: sequence, chromosome assignment and genetic analysis in dogs of different breeds.
TLDR
The cloning of the canine homologue of MSX2, the determination of its structure, sequence and localization of the gene to dog chromosome 4q23 are described and several conserved transcription factor binding motifs have been identified and their significance discussed.

References

SHOWING 1-10 OF 33 REFERENCES
Chicken homeobox gene Msx-1: structure, expression in limb buds and effect of retinoic acid.
TLDR
Both ectodermal and mesenchymal expression in limb bud were rapidly suppressed by local treatment of retinoic acid which can generate mirror-image duplication of digits, indicating that retinoics acid alters the marginal presumptive non-cartilage forming mesenchyme cell lineage through suppression of Msx-1 expression.
Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth.
TLDR
It is found that the maintenance of homeobox gene expression in the tooth is dependent upon tissue interactions, and expression of msx 1 in jaw mesenchyme requires a non-specific epithelial signal, whereas msx 2 expression in either epithelium or mesenchYme requires reciprocal interactions between specialized dental cell populations.
The Msh-like homeobox genes define domains in the developing vertebrate eye.
TLDR
The results suggest that these genes are involved in defining the region that gives rise to the inner layer of the optic cup and in patterning this tissue to define the iris, ciliary body and retina.
Molecular cloning and sequence of bovine Msx-1 homeobox-containing gene cDNA from a bovine odontoblast library.
Screening of a bovine odontoblast cDNA library from developing incisor with murine Msx-1 and Msx-2 cDNA probes led to the isolation of three positive clones. All of them encoded for a sequence of a
Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs.
TLDR
Data suggest that a ubiquitous CP1-like CAAT factor and a cell type-restricted homeodomain containing (Msx or POU family) transcription factor interact with the proximal rat OC promoter to direct appropriate basal OC transcription in osteoblastic cells.
Hox‐7, a mouse homeobox gene with a novel pattern of expression during embryogenesis.
TLDR
The pronounced accumulation and regional localization of Hox‐7 transcripts in mandibular and limb processes point to a specific morphogenetic role for this mouse homeobox gene.
Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape.
TLDR
The demonstration of the precise expression patterns of Hox-8 in the early dental placodes and their subsequent association with the enamel knot, septum and navel provide the first molecular clues to the basis of patterning in the dentition and the association of tooth position with tooth shape.
The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro.
TLDR
The expression of Hox 7.1 during craniofacial development in the mouse embryo between days 8 and 16 of development is examined, finding expression in the mesenchyme of the dental papilla and follicle is maximal at the cap stage of development and progressively declines in the bell stage prior to differentiation of odontoblasts and ameloblasts.
...
1
2
3
4
...