[Molecular biology of soft-tissue sarcomas].

@article{Coindre2010MolecularBO,
  title={[Molecular biology of soft-tissue sarcomas].},
  author={J. M. Coindre},
  journal={Bulletin du cancer},
  year={2010},
  volume={97 11},
  pages={
          1337-45
        }
}
Sarcomas represent a heterogeneous group of tumors with a complex and poorly reproducible classification. However, in the last ten years, several specific genetic alterations have been described allowing a molecular classification with: 1) sarcomas with a specific translocation which can be used as a diagnostic marker. These translocations can be demonstrated by RT-PCR or by FISH with commercially available break apart probes ; 2) sarcomas with simple genomic profile showing amplification of a… CONTINUE READING
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