[Molecular biology of Fas antigen-Fas ligand system].

Fas antigen is a type I membrane protein of 45 kDa that belongs to the tumor necrosis factor (TNF)/nerve growth factor receptor family. The binding of agonistic anti-Fas antibody or Fas ligand to Fas antigen induces apoptosis. The unique motif "death domain" in the cytoplasmic region of Fas antigen is essential for the initiation of apoptosis. Fas ligand is… (More)