[Mode of inhibitory action of propiverine hydrochloride on the micturition movements of the bladder in dogs].

@article{Kaneko1989ModeOI,
  title={[Mode of inhibitory action of propiverine hydrochloride on the micturition movements of the bladder in dogs].},
  author={Shuji Kaneko and Koutarou Kitazato and Y. Yamazaki and Hiroki Okada},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={1989},
  volume={94 2},
  pages={
          151-7
        }
}
  • S. Kaneko, K. Kitazato, H. Okada
  • Published 1 August 1989
  • Medicine, Biology, Chemistry
  • Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Propiverine hydrochloride (P-4) is a new derivative of benzilic acid. The effect of P-4 on the vesico-detrusor reflex (corresponding to the first reflex of Barrington) in anesthetized or decerebrated dogs was studied to elucidate the mode of action of the drug. When bladder contraction was induced by electrical stimulation of the distal ending of the pelvic nerve under the bilateral pelvic nerve and hypogastric nerve transection, P-4 (2, 5 and 10 mg/kg, i.v.) significantly inhibited the… 
2 Citations
Pharmacokinetic Studies on Propiverine Hydrochloride. Metabolites in Urinary Bladder, Other Tissues and Urine of Rats.:Metabolites in Urinary Bladder, Other Tissues and Urine of Rats
TLDR
All pharmacologically active compounds such as the unchanged compound, 1-methyl-4-piperidyl benzilate N-oxide (DPr-P-4 (N→O)), Dpt-p-4 and P-4 were present in the urinary bladder, a target organ for P- 4, at higher concentrations than in the plasma.
Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine
TLDR
The poor and extensive metabolizers of debrisoquine did not differ significantly with regard to the concentration time behaviour of the active drug components, pattern of major metabolites, adverse drug reactions or any pharmacodynamic parameters measured.