[Mode of action of terrazoleon Mucor mucedo].

@article{Lyr1977ModeOA,
  title={[Mode of action of terrazoleon Mucor mucedo].},
  author={Horst Lyr and Gerald F. Casperson and B Laussmann},
  journal={Zeitschrift fur allgemeine Mikrobiologie},
  year={1977},
  volume={17 2},
  pages={
          117-29
        }
}
It is assumed that the fungistatic effect of terrazol in Mucor mucedo is induced by a liberation of phospholipases within within the mitochondria and perhaps at other membranes. In isolated mitochondria a rapid formation of lysolecithin can be demonstrated at low concentrations of terrazol. This would explain the lytic symptoms in mitochondria visible by electron microscopy. Lipid peroxidation could not be demonstrated. The only antidots at present known for the growth inhibiting effect of… 
5 Citations
[Effect of pentachloronitrobenzene (PCNB) on the ultrastructure of Mucor mucedo and Phytophthora cactorum].
TLDR
The effect of PCNB in various concentrations on the ultrastructure of Mucor mucedo and phytophthora cactorum was analyzed and a diffuse lysis of the internal structure of the mitochondria differs markedly from the lysis induced by etridiazol.
Wirkung von Pentachlornitrobenzol (PCNB) auf die Ultrastruktur von Mucor mucedo und Phytophthora cactorum
TLDR
The most striking effect in both fungi was a diffuse lysis of the internal structure of the mitochondria which differs markedly from the lysis induced by etridiazol (terrazol).

References

SHOWING 1-4 OF 4 REFERENCES
[Effect of terrazol on the ultrastructure of Mucor mucedo].
TLDR
Terrazol, a systemic fungicide showing high specifity to oomycetes, inhibits the apical growth of hyphae and promotes at lower concentrations the thickening of the cell wall in Mucor mucedo, and the fine structure of some membrane systems is influenced.
[Mechanism of action of terrazol].
TLDR
Higher concentrations of terrazol inhibit the growth of a large number of fungi, but oomycetes are most sensitive, and significant observations are vacuolization of the mitochondrial cristae, invagination of the cytoplasmic membrane, and thickening of the cell wall.
EFFECT OF THE ANTIBIOTIC, CYCLOHEXIMIDE, ON THE METABOLISM AND GROWTH OF SACCHAROMYCES PASTORIANUS
TLDR
A block of glutamine synthesis by cycloheximide may be sufficient to account for the toxicity of the antibiotic, but the failure of exogenous sources of glutamines to reverse the toxicity indicates that other reactions in cell metabolism may be as sensitive to cyclo heximide as the synthesis of glutamate.