[Misregulation of P-TEFb activity: pathological consequences].

  title={[Misregulation of P-TEFb activity: pathological consequences].},
  author={Lisa Muniz and Tam{\'a}s Kiss and Sylvain Egloff},
  journal={Medecine sciences : M/S},
  volume={28 2},
P-TEFb stimulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA pol II and antagonizing the effects of negative elongation factors. Its cellular availability is controlled by an abundant non coding RNA, conserved through evolution, the 7SK RNA. Together with the HEXIM proteins, 7SK RNA associates with and sequesters a… CONTINUE READING