Corpus ID: 42232505

[Methoxyflurane and ethanol do not inhibit the neuronal uptake of noradrenaline (uptake 1) at the desipramine binding site].

@article{Kress1990MethoxyfluraneAE,
  title={[Methoxyflurane and ethanol do not inhibit the neuronal uptake of noradrenaline (uptake 1) at the desipramine binding site].},
  author={H. Kress and E. Sch{\"o}mig},
  journal={Der Anaesthesist},
  year={1990},
  volume={39 7},
  pages={
          371-4
        }
}
  • H. Kress, E. Schömig
  • Published 1990
  • Medicine
  • Der Anaesthesist
  • We recently demonstrated that the net accumulation of 3H-norepinephrine in the rat pheochromocytoma cell line PC12 was reduced by anesthetic concentrations of n-alkanols and the volatile anesthetics halothane, enflurane, isoflurane, and methoxyflurane. In PC12 cells, as in adrenergic neurons, norepinephrine is transported across the plasma membrane by a saturable, high-affinity, carrier-mediated mechanism (uptake1), which follows Michaelis-Menten kinetics, is energy- and sodium-dependent, and… CONTINUE READING