[Methotrexate in therapy of gastrointestinal diseases].
@article{Schrder1999MethotrexateIT,
title={[Methotrexate in therapy of gastrointestinal diseases].},
author={O. Schr{\"o}der and J. Stein},
journal={Zeitschrift fur Gastroenterologie},
year={1999},
volume={37 7},
pages={
623-37
}
}This review is not only a comprehensive synopsis of the published data on methotrexate treatment for inflammatory bowel disease and primary biliary cirrhosis but gives also an overview about acting mechanisms, pharmacologic properties and limiting toxicities of low-dose methotrexate. Methotrexate and its polyglutamate analogues are structurally related to folic acid and inhibit many enzymes in the metabolic pathway of folic acid. Long-term low-dose methotrexate treatment (7.5-25 mg) inhibits… Expand
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