[Metabolites of injected chlorogenic acid in rats].

  title={[Metabolites of injected chlorogenic acid in rats].},
  author={Cen Xie and Da-fang Zhong and Xiaoyan Chen},
  journal={Yao xue xue bao = Acta pharmaceutica Sinica},
  volume={46 1},
Chlorogenic acid (5-CQA) is one of the major components in some Chinese herbal injections. However, the metabolism of 5-CQA in rats after intravenous injection has not been determined. An ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) method was applied to identify the metabolites in bile, urine, feces and plasma after a single intravenous administration of 10 mg x kg(-1) 5-CQA to rats. Using MSE and mass defect filter techniques, a… CONTINUE READING