[Metabolism of Ro 21-5998 (mefloquine) in the rat (author's transl)].

Abstract

After administration of 15 mg/kg 14C-Ro 21-5998/001 i.p. to rats, the metabolite patterns in feces, urine, bile and blood were compared. Metabolites from feces were identified by GC/MS, in all other cases by TLC. The main component in the feces consists of mefloquine (Ro 21-5998). In addition the acid Ro 21-5104, a derivative of mefloquine with a hydroxy… (More)

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