[Membrane receptors and cell transformation].

  • Masaaki Shibuya
  • Published 1992 in
    Nihon rinsho. Japanese journal of clinical…


Here I discuss quantitative and qualitative activation of several receptor-type molecules in tumor cells. Recently we have shown that EGF-R gene is frequently mutated in human glioblastoma. Mutant EGF-R had a 801-bp deletion within the ligand binding domain, and showed a ligand-independent, constitutive elevation of tyrosine kinase activity. This EGF-R… (More)


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