[Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis].

@article{Takeda2013MedicinalCA,
  title={[Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis].},
  author={Shuso Takeda},
  journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan},
  year={2013},
  volume={133 10},
  pages={
          1093-101
        }
}
  • Shuso Takeda
  • Published 2013
  • Chemistry, Medicine
  • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Considerable attention has focused on cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, and it has been reported to possess diverse biological activities. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), several studies have investigated whether CBDA itself is biologically active. In the present report, the author summarizes findings indicating that; 1) CBDA is a selective cyclooxygenase-2 (COX-2… Expand
Cannabinoids as anticancer and neuroprotective drugs: Structural insights and pharmacological interactions—A review
Abstract Cannabinoids are the major chemical constituents of the plant Cannabis sativa L. and are known to exhibit a wide range of pharmacological effects viz., psychotropic, analgesic, anticancer,Expand
Δ9-Tetrahydrocannabinol targeting estrogen receptor signaling: the possible mechanism of action coupled with endocrine disruption.
  • Shuso Takeda
  • Chemistry, Medicine
  • Biological & pharmaceutical bulletin
  • 2014
TLDR
The possible mechanism(s) of the Δ(9)-THC-mediated disruption of E2/ERα signaling by presenting recent findings as well are discussed. Expand
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
TLDR
The concept that CBDA is a functional down-regulator of COX-2 through the abrogation of PPARβ/δ-related signaling, at least in part, in MDA-MB-231 cells is supported. Expand
Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
TLDR
A possible mechanism by which CBDA abrogates the expression of COX-2 via the selective down-regulation of c-fos, one component of the activator protein-1 (AP-1) dimer complex, a transcription factor for the positive regulation of the COX2 gene is described. Expand
Future Aspects for Cannabinoids in Breast Cancer Therapy
TLDR
Cannabinoids are already administered to breast cancer patients at advanced stages of the disease, but they might also be effective at earlier stages to decelerate tumor progression. Expand
Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells.
TLDR
Results obtained here demonstrated that cannabidiolic acid had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and CBDA may possess the ability to suppress genes that are positively involved in the metastasis of cancer cells in vitro. Expand
Cannabidiol-2',6'-dimethyl ether stimulates body weight gain in apolipoprotein E-deficient BALB/c. KOR/Stm Slc-Apoe(shl) mice.
TLDR
The effects of CBDD on body weight changes in mice were focused on, and it was demonstrated that it stimulated body weight gain in apolipoprotein E (ApoE)-deficient BALB/c. Expand
DNA microarray analysis of genes in highly metastatic 4T1E/M3 murine breast cancer cells following exposure to cannabidiolic acid
TLDR
DNA microarray analyses of 4T1E/M3 cells treated with CBDA revealed that the expression of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β (TGF-β) inducible gene H3 (BIGH3), and parathyroid hormone-related protein (PTHrP) was markedly down-regulated, which indicated that these molecules were mutually involved in the bone metastasis of breast cancer cells. Expand
Les représentations des médecins généralistes concernant le cannabis, l'acool et le tabac. Enquête prospective auprès de 2186 médecins généralistes libéraux lorrains
Objectifs: l’etude des perceptions relatives aux substances addictives represente un enjeu majeur de prevention et la prise en charge des addictions est fortement influencee par les representationsExpand