[Mechanisms of action of statins and their pleiotropic effects].

  title={[Mechanisms of action of statins and their pleiotropic effects].},
  author={Jean Davignon and Laurence Mabile},
  journal={Annales d'endocrinologie},
  volume={62 1 Pt 2},
This brief review and update considers a few aspects of the mechanisms of action of statins, especially those related to some of the pleiotropic effects that have clinical relevance. The beneficial effect on endothelial dysfunction is a class effect that is related not only to the lowering of plasma LDL-cholesterol but also to a direct effect on nitric oxide (NO) production. It is an early and sustained effect, linked to oxidative processes, that deserves particular attention since endothelial… CONTINUE READING