[Mechanism of hepatoprotective action of methionine and composition "Metovitan" against a background of antituberculosis drug administration to rats].

@article{Anisimova2013MechanismOH,
  title={[Mechanism of hepatoprotective action of methionine and composition "Metovitan" against a background of antituberculosis drug administration to rats].},
  author={Svitlana I Anisimova and H V Donchenko and I. M. Parkhomenko and Valentina Mykolaivna Kovalenko},
  journal={Ukrains'kyi biokhimichnyi zhurnal},
  year={2013},
  volume={85 2},
  pages={59-67}
}
Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition "Metovitan" given with anti-TB drugs provided a correction of these abnormalities, that is evidenced by modulation of the level of CYP3A2, CYP2C23, CYP2E1 gene expression and antioxidant activity, inhibition of lipid peroxidation… CONTINUE READING