[Mechanism of growth inhibition effect of 3', 4', 5, 7-tetrahydroxyflavone on A549 cells].

@article{Hu2012MechanismOG,
  title={[Mechanism of growth inhibition effect of 3', 4', 5, 7-tetrahydroxyflavone on A549 cells].},
  author={Chunping Hu and Xueting Cai and Tingting Hu and Wuguang Lu and Peng Cao},
  journal={Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica},
  year={2012},
  volume={37 9},
  pages={1259-64}
}
OBJECTIVE To study luteolin-induced non-small cell lung cancer cell line A549 apoptosis and the molecular mechanism for inhibiting its cycle arrest (G2 stage). METHOD MTT assay showed that luteolin had obvious inhibitory effect on A549 and indicated the half inhibition ratio (IC50). Cell cycle and apoptosis were detected by Hoechst 33258 nuclear staining assay, Annexin V-FITC/PI double staining and flow cytometry. Western blotting assay revealed changes in cycle and apoptosis-related proteins… CONTINUE READING
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