[Mechanism of efficacy of erythromycin on diffuse panbronchiolitis--effect of erythromycin on cytokine mRNA expression in human whole blood model].

@article{Akiyoshi1994MechanismOE,
  title={[Mechanism of efficacy of erythromycin on diffuse panbronchiolitis--effect of erythromycin on cytokine mRNA expression in human whole blood model].},
  author={Hiroya Akiyoshi and Junichi Honda and Sukita Nakahara and Shiro Tokisawa and Naoki Tokunaga and Yukari Ichikawa and Kotaro Oizumi},
  journal={Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases},
  year={1994},
  volume={68 2},
  pages={
          209-16
        }
}
Recently, "low-dose and long-term" erythromycin (EM) has been reported to be effective in treatment of diffuse panbronchiolitis (DPB), but its mechanism is still obscure. We studied the effect of EM on cytokine mRNA expression by using LPS-stimulated human whole blood as an experimental vivo model. IL-8 mRNA was expressed in biphasic fashion with peak expression at 6 hours and 20 hours from the start of LPS stimulation. When whole blood was pretreated with EM (2 micrograms/ml) for 1 hours. IL-8… CONTINUE READING