[Mechanism of action of tetrahydro-N, N-dimethyl-5, 5-diphenyl-3-furanemethanamine, a putative nootropic, anti-epileptic and antidepressant compound].

@article{Vamvakides2002MechanismOA,
  title={[Mechanism of action of tetrahydro-N, N-dimethyl-5, 5-diphenyl-3-furanemethanamine, a putative nootropic, anti-epileptic and antidepressant compound].},
  author={Alexander Vamvakides},
  journal={Annales pharmaceutiques francaises},
  year={2002},
  volume={60 6},
  pages={415-22}
}
Pharmacological studies on tetrahydro-N, N-dimethyl-5, 5-diphenyl-3-furanemethanamine (AE14) pointed out its prominent action in the passive avoidance test, its antagonist effect on electrogenic (maximal electroshock, MES) or pentetrazole-induced tonic convulsions, and its anti-immobility effect in the forced swim test (FST) in mice. These pharmacological data suggest that AE14 could exhibit nootropic, antiepileptic and antidepressant actions. Molecular pharmacology studies (receptology… CONTINUE READING

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