• Corpus ID: 2662653

[Mechanism of action of myotoxins isolated from snake venoms].

@article{Gutirrez1984MechanismOA,
  title={[Mechanism of action of myotoxins isolated from snake venoms].},
  author={Jos{\'e} Mar{\'i}a Guti{\'e}rrez and Luis Cerdas},
  journal={Revista de biologia tropical},
  year={1984},
  volume={32 2},
  pages={
          213-22
        }
}
Biochemically and pharmacologically, myotoxins isolated from snake venoms can be placed in four main groups: myotoxic phospholipases A, low molecular weight basic toxins, cardiotoxins, and hemorrhagic myotoxins. The myotoxic phospholipases A notexin, taipoxin, crotoxin, and Bothrops asper myotoxin induce muscle necrosis by first affecting the integrity of the plasma membrane, thereby inducing a calcium influx that culminates in cell death. The small basic myotoxin crotamine acts on the voltage… 
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