[Mary Lyon and the hypothesis on X-chromosome inactivation].

  title={[Mary Lyon and the hypothesis on X-chromosome inactivation].},
  author={Karen Helene {\O}rstavik},
  journal={Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke},
  volume={135 12-13},
  • K. Ørstavik
  • Published 30 June 2015
  • Biology, Medicine
  • Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
1 Citations
Dosage compensation in the process of inactivation/reactivation during both germ cell development and early embryogenesis in mouse
Analysis of RNA-seq data from cells undergoing the process of inactivation/reactivation provides direct evidence that the average gene dosage of the single active X chromosome is upregulated to achieve a similar level to that of two active X chromosomes and autosomes present in two copies. Expand


Mary F. Lyon (1925–2014)
Mary Lyon and the hypothesis of random X chromosome inactivation
The 50th anniversary of Mary Lyon’s 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females, provides an opportunityExpand
The Gift of Observation: An Interview with Mary Lyon
In a link with posterity, her last name now forms the basis for a word—“lyonization”—synonymous with the mammalian random X-inactivation process that she first hypothesized a half-century ago. Expand
X chromosome inactivation in clinical practice
This review focuses on medical issues related to XCI in X-linked disorders, and on the value of X inactivation analysis in clinical practice. Expand
Do LINEs Have a Role in X-Chromosome Inactivation?
  • M. Lyon
  • Medicine, Biology
  • Journal of biomedicine & biotechnology
  • 2006
Evidence, accruing from the human genome sequencing project and other sources, confirms that mammalian X-chromosomes are indeed rich in L1s, except in regions where there are many genes escaping XCI. Expand
X-chromosome inactivation: role in skin disease expression.
  • R. Happle
  • Biology, Medicine
  • Acta paediatrica (Oslo, Norway : 1992). Supplement
  • 2006
In the various X-linked skin disorders, affected women show quite dissimilar degrees of involvement and forms of manifestation because X inactivation may give rise to different patterns of functional mosaicism. Expand
X Chromosome Inactivation: No longer ‘all-or-none’
  • M. Lyon
  • Biology
  • European Journal of Human Genetics
  • 2005
The X Chromosome and the Female Survival Advantage
This paper illustrates how a genetic observation combined with demographic insight and a modified genetic‐epidemiologic design (a twin study) provides evidence that part of the sex difference in survival can be attributed to the fact that females have two X chromosomes and males have only one, a result of potential interest for genetics, epidemiology, and demography. Expand
Skewed X chromosome inactivation in a female with haemophilia B and in her non-carrier daughter: a genetic influence on X chromosome inactivation?
X inactivation analysis in a family with haemophilia B showed extremely skewed X inactivation both in a female haemophile patient and in her non-carrier daughter, indicating a possible genetic influence on X chromosome inactivation in this family. Expand
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome. Expand