[MDR (multidrug resistance) in hepatocarcinoma clinical-therapeutic implications].

  title={[MDR (multidrug resistance) in hepatocarcinoma clinical-therapeutic implications].},
  author={Luisa Petraccia and Paolo Onori and Roberta Sferra and Maria Cristina Lucchetta and Giovanna Liberati and Mario Grassi and Eugenio Gaudio},
  journal={La Clinica terapeutica},
  volume={154 5},
Our purpose was to summarize current knowledge on "multidrug resistance", or MDR, an intrinsic or acquired cross resistance to a variety of structurally and functionally unrelated drugs, still representing one of the major problems in the therapy of cancer and other diseases. MDR depends on various mechanisms, the best known being the activity of ABC transport proteins, mainly Pgp, MDR1 gene product,and MRPs; but also other transporters can cause resistance, for example TAP, a peptide… CONTINUE READING
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