[Lung cancer risk and genetic polymorphism at the glutathione S-transferase P1 locus in male Japanese].

@article{Yamamura2000LungCR,
  title={[Lung cancer risk and genetic polymorphism at the glutathione S-transferase P1 locus in male Japanese].},
  author={K Yamamura and Chikako Kiyohara and Yoichi Nakanishi and Koichi Takayama and Nobuyuki Hara},
  journal={Fukuoka igaku zasshi = Hukuoka acta medica},
  year={2000},
  volume={91 8},
  pages={203-6}
}
The glutathione S-transferases (GSTs) are widely expressed in mammalian tissues and involved in Phase II detoxification reactions. The GSTs form a supergene family consisting of four distinct families, named alpha (GSTA), mu (GSTM) theta (GSTT) and pi (GSTP). Several of the GST genes are polymorphic in humans and are currently being investigated as possible cancer-risk modifiers. Among the GST genes, we examined GSTP1 polymorphism in exon 5 among male lung cancer patients (n = 86, male Japanese… CONTINUE READING

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