[Long-term expansion of T cell progenitors by JAK3 gene transduced primitive hematopoietic cells in vitro].

@article{Zhao2006LongtermEO,
  title={[Long-term expansion of T cell progenitors by JAK3 gene transduced primitive hematopoietic cells in vitro].},
  author={Sheng-ming Zhao and Xi-chun Gu and Nai-bai Chang and Xiao-dong Xu and Ming-ting Peng},
  journal={Zhonghua yi xue za zhi},
  year={2006},
  volume={86 24},
  pages={
          1701-5
        }
}
OBJECTIVE To explore whether activation of the JAK3-signaling pathway can stimulate long-term expansion of the earliest T cell progenitors from transduced primitive hematopoietic cells and evaluate their potential ability of committed differentiation. METHODS A retrovirus vector (RV) containing JAK3 gene, two binding sites for chemical inducers of dimerization (AP20187), and green fluorescence protein (GFP), MGI-F(2)JAK3, was constructed. The RV vector MGI-F(2)JAK3 was then transduced into… CONTINUE READING