[Li-Fraumeni: Will the detection in families increase the survival of its members?]

@article{Gargallo2019LiFraumeniWT,
  title={[Li-Fraumeni: Will the detection in families increase the survival of its members?]},
  author={Pablo Gargallo Gargallo and Vanessa Rubio Segura and Yania Y{\'a}{\~n}ez and Julia Balaguer and Adela Ca{\~n}ete},
  journal={Anales de pediatria},
  year={2019},
  volume={90 1},
  pages={
          54-55
        }
}
Li-Fraumeni syndrome is a rare cancer predisposition syndrome with an autosomal dominant pattern of inheritance and of variable phenotypic expression associated with germline mutations in gene TP53. This disease predisposes to the development of a wide variety of malignant tumours. The most frequent tumours are soft-tissue sarcomas (rhabdomyosarcoma and others), osteosarcoma, breast cancer in premenopausal women, hypodiploid leukaemia, brain tumours (choroid plexus carcinoma, glioblastoma and… CONTINUE READING
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