[Langerhans-cell histiocytosis (histiocytosis X) in children].

  title={[Langerhans-cell histiocytosis (histiocytosis X) in children].},
  author={H. Michael Carstensen and Kim T Ornvold},
  journal={Ugeskrift for laeger},
  volume={155 23},
Langerhans cell histiocytosis (LCH), formerly histiocytosis X, is a rare disorder of unknown aetiology and pathogenesis which is characterized by clinical heterogeneity and an unpredictable course. LCH is considered to be a reactive, proliferative disease. The pathognomonic cell in the lesion has been shown to be identical or very similar to the Langerhans cell. Immunophenotyping studies have shown the cell to be CD1a (OKT-6), S-100 protein, HLA-DR, and CD4 positive; ultrastructurally, the… CONTINUE READING
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