[Laminin-dependent growth arrest of human hepatic carcinoma cell line, HuH-7, in association with expression of p21/WAF-1 protein].

Laminin-overlay to the culture of a human hepatocellular carcinoma cell line, HuH-7, resulted in changes in the cell behavior; suppression of the cell growth, conversion of the cell morphology, and the elevated secretion of cellular AFP in the culture medium, implying that the cells had undergone apparent differentiation in vitro. Together with the… CONTINUE READING