[Lack of effect of cicletanine and its sulfoconjugated metabolite on the thiazide receptor expressed in Xenopus oocytes].

@article{Monroy1999LackOE,
  title={[Lack of effect of cicletanine and its sulfoconjugated metabolite on the thiazide receptor expressed in Xenopus oocytes].},
  author={A. Monroy and C. Plata and G. Gamba and M. T. Droy-lefaix and R. Garay},
  journal={Archives des maladies du coeur et des vaisseaux},
  year={1999},
  volume={92 8},
  pages={
          1001-4
        }
}
  • A. Monroy, C. Plata, +2 authors R. Garay
  • Published 1999
  • Biology, Medicine
  • Archives des maladies du coeur et des vaisseaux
  • UNLABELLED Although the renal receptor at which cicletanine acts is unknown, cicletanine was assumed to act like thiazide diuretics. Here we tested cicletanine and its natriuretic metabolite, cicletanine-sulfate, for inhibitory activity against the thiazide-sensitive NaCl cotransporter expressed in Xenopus oocytes. The renal thiazide-sensitive NaCl cotransporter was expressed in Xenopus laevis oocytes injected with rat cRNA TSCr (TSCr: thiazide-sensitive cotransporter from rat kidney) and both… CONTINUE READING
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