• Medicine
  • Published in
    Zhejiang da xue xue bao. Yi…

[LIM kinases and their roles in the nervous system].

  title={[LIM kinases and their roles in the nervous system].},
  author={Ru-yi Zhang and Yue-min Ding and Li-huang Zhang},
  journal={Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences},
  volume={43 1},
LIM kinase-1 (LIMK1) and LIM kinase-2 (LIMK2) are kinases that have serine/threonine and tyrosine dual specificity. Although they show significant structural similarity, LIMK1 and LIMK2 have different expression patterns, subcellular localization, and functions. Activation of LIM kinases regulates the downstream of Rho GTPases, and influences the architecture of the actin cytoskeleton by regulating the activity of cofilin. Recent studies have shown that LIM kinases play important roles in the… CONTINUE READING