[KIT and KIT: from biology to clinical use].

Abstract

Scientific knowledge on gastrointestinal stromal tumors (GIST) has highly progressed over the last 10 years. The molecular bases of oncogenic transformation, KIT activating mutations, were identified in 1998 by Hirota et al. The product of KIT proto-oncogene, KIT protein, is a transmembrane receptor with tyrosine kinase activity. Tyrosine kinase inhibitors… (More)
DOI: 10.1684/bdc.2011.1386

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.