[Investigation on silymarin impact on lipopolysaccharide induced inflammation model based on arachidonic acid metabolism pathway].

@article{Mai2017InvestigationOS,
  title={[Investigation on silymarin impact on lipopolysaccharide induced inflammation model based on arachidonic acid metabolism pathway].},
  author={Danti Mai and Chan Yang and Y. Xue and Y. Wang and C. Yan},
  journal={Se pu = Chinese journal of chromatography},
  year={2017},
  volume={35 6},
  pages={
          578-586
        }
}
  • Danti Mai, Chan Yang, +2 authors C. Yan
  • Published 2017
  • Chemistry, Medicine
  • Se pu = Chinese journal of chromatography
  • The objective of this research is to investigate the suppressive effect of silymarin on vitro cell culture model of inflammatory macrophage RAW264.7 induced by Kdo2-Lipid A, and explore its mechanism based on cell metabonomics. Ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was used in the cell metabonomic assay to quantitative analysis of metabolites related to eicosanoids pathway. Then chemometric approaches such as principal component… CONTINUE READING
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    References

    US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM
    • Chinese Journal of Chro⁃ matography,
    • 2016