• Corpus ID: 30576956

[Interactions of theophylline and nifedipine].

@article{Luther1990InteractionsOT,
  title={[Interactions of theophylline and nifedipine].},
  author={R Luther and Hildegarde E. Wichert and E K{\"o}hler and Peter Banditt and H. Walther},
  journal={Zeitschrift fur Erkrankungen der Atmungsorgane},
  year={1990},
  volume={174 2},
  pages={
          97-103
        }
}
We analyzed theophylline serum levels in steady state of 10 subjects (out of them 7 patients with chronic obstructive lung disease (COLD) and 3 volunteers). Serum theophylline concentrations were measured after oral application of 3 X 280 mg theophylline (Theophyllin retard 280 mg) and in a second condition after accessory administration of 3 X 20 mg nifedipine (Corinfar). No significant difference was found concerning theophylline levels before and after nifedipine application. The ventilation… 
1 Citations
Influence of Endogenous and Exogenous Effectors on the Pharmacokinetics of Theophylline
TLDR
Age and concomitant disease are the major endogenous effectors influencing biotransformation of theophylline, whereas biorhythms, gender and pregnancy are of lesser importance.