Corpus ID: 33307983

[Interaction between ipriflavone and other drugs in metabolism in vitro].

@article{Hu2004InteractionBI,
  title={[Interaction between ipriflavone and other drugs in metabolism in vitro].},
  author={X. Hu and T. Yao},
  journal={Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences},
  year={2004},
  volume={33 1},
  pages={
          21-3
        }
}
  • X. Hu, T. Yao
  • Published 2004
  • Chemistry, Medicine
  • Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
OBJECTIVE To investigate the metabolism-based interaction between ipriflavone(IP) and other drugs in vitro. METHODS IP and propafenone or estradiol, or other drugs were co-incubated with rat liver microsome induced by beta-naphthoflavone. The concentrations of residual substrate in microsomal incubates were determined by HPLC. RESULT The metabolism of propafenone (10 microg/ml) incubated with 2 microg/ml or 50 microg/ml IP was markedly inhibited compared with control group(P<0.01). While… Expand