• Corpus ID: 26131318

[Inter- and intra-individual variations on the disposition of piroxicam. Pharmacokinetics in healthy man and the patient with renal insufficiency].

@article{Dupont1982InterAI,
  title={[Inter- and intra-individual variations on the disposition of piroxicam. Pharmacokinetics in healthy man and the patient with renal insufficiency].},
  author={Didier Dupont and Pierre Dayer and Luc P. Balant and A. Gorgia and Jean Fabre},
  journal={Pharmaceutica acta Helvetiae},
  year={1982},
  volume={57 1},
  pages={
          20-6
        }
}
7 Citations
Indirect assessment of the enterohepatic recirculation of piroxicam and tenoxicam
SummaryTo assess the extent of enterohepatic recycling of piroxicam and tenoxicam, their pharmacokinetics have been compared in the absence and presence of concomitant treatment with cholestyramine.
Pharmacokinetics of tenoxicam in patients with impaired renal function
TLDR
The urinary excretion of 5′OH-tenoxicam fell with decreasing renal function, so no dosage adjustment should be necessary and the usual daily dose of tenoxicam may be administered once daily to patients with renal failure.
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TLDR
Although the development of sudoxicam was stopped because of frequent adverse effects, this drug is interesting because, unlike other oxicams, its appears to have nonlinear elimination pharmacokinetics.
Protein Binding as a Primary Determinant of the Clinical Pharmacokinetic Properties of Non-Steroidal Anti-Inflammatory Drugs
TLDR
The clinical pharmacokinetic properties of future NSAIDs which emerge from the same chemical classes as currently available NSAIDs can be expected to be profoundly influenced by the extent and affinity of binding of the drugs to proteins.
The Effect of Cimetidine on Serum Concentrations of Piroxicam
TLDR
To evaluate the effect of cimetidine on serum concentrations of piroxicam, 10 healthy male volunteers were administered a single 20‐mg oral dose of p IRXS to characterize its pharmacokinetics and high‐performance liquid chromatography was used.
Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs
TLDR
The most important interactions with NSAIDs are those involving the oral anticoagulants and oral hypoglycaemic agents, though not all NSAIDs have been found to interact with these drugs.