[Insulin-like effects of anti-insulin-receptor antibodies on cultured rat hepatocytes].

  • Ritsuko Shimoyama
  • Published 1985 in
    [Hokkaido igaku zasshi] The Hokkaido journal of…

Abstract

The effects of two anti-insulin-receptor antibodies (AIRA) on 125I-insulin binding, glycogenesis, amino-isobutyric acid (AIB) transport and insulin receptor down-regulation on cultured rat hepatocytes were examined. Two AIRA blocked insulin receptor dose-dependently and caused a decrease in available insulin receptor on hepatocytes. AIRA mimicked insulin… (More)

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