[Insertion of the bacterial gene for dihydrofolate reductase into colony-forming cells of mouse bone marrow].

@article{Titomirov1985InsertionOT,
  title={[Insertion of the bacterial gene for dihydrofolate reductase into colony-forming cells of mouse bone marrow].},
  author={A V Titomirov and Alexej Pereverzev and L I Stepan'ian and O I Podgornaia and O N Aprelikova},
  journal={Tsitologiia},
  year={1985},
  volume={27 10},
  pages={1183-8}
}
Introduction of the plasmid containing the methotrexate-resistant (Mtx-r) bacterial gene of dihydrofolate reductase (DHFR) under the control of the early promoter of SV 40 into the donor bone cells of the mouse with subsequent transplantation of the cells into lethally irradiated mice results in the increase in the life span of mice under conditions of methotrexate selection. It is due to the stable transformation of the bone marrow colony-forming cells with the plasmic DNA and the synthesis of… CONTINUE READING

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