[Inhibitory mechanism of melanin synthesis by glutathione].


Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA. The inhibition of melanin synthesis was recovered by increasing the concentration of L-DOPA, but not recovered by increasing tyrosinase. Glutathione inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was aggregated within 1 h… (More)


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@article{Matsuki2008InhibitoryMO, title={[Inhibitory mechanism of melanin synthesis by glutathione].}, author={Mitsuo Matsuki and Toshihiko Watanabe and Ayako Ogasawara and Takeshi Mikami and Tatsuji Matsumoto}, journal={Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan}, year={2008}, volume={128 8}, pages={1203-7} }