[Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein].

@article{Ohyagi2007InhibitionON,
  title={[Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein].},
  author={Yasumasa Ohyagi and Katsue Miyoshi and Linqing Ma and Kyoko Motomura and Jun-ichi Kira},
  journal={Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology},
  year={2007},
  volume={27 2},
  pages={57-62}
}
Inhibition of aggregation of amyloid p-protein (AP) and promotion of extracellular AM removal are known as potent therapeutic tools for Alzheimer's disease (AD). While, the importance of Af342 accumulating in neurons has recently been suggested, and we have reported that A/42 accumulating in the neurons moves into the nucleus, activating p53 mRNA expression and leading to apoptosis (Ohyagi et al, FASEB J, 2005). Moreover, intraneuronal Ap is reported to induce mitochondrial dysfunction via… CONTINUE READING