[Inhibition of human platelet aggregation by a new class of soluble guanylate cyclase inhibitor, generating nitric oxide].

@article{Belushkina1994InhibitionOH,
  title={[Inhibition of human platelet aggregation by a new class of soluble guanylate cyclase inhibitor, generating nitric oxide].},
  author={N. N. Belushkina and N. B. Grigor'ev and Irina S Severina},
  journal={Biokhimiia},
  year={1994},
  volume={59 11},
  pages={1689-97}
}
Diacetidine-di-N-oxide derivatives have been found to be capable of generating nitric oxide (NO) non-enzymatically, via an entirely new mechanism--NO splitting at physiological pH. The effects of the synthesized compounds on the human platelet soluble guanylate cyclase activity and ADP-induced human platelet aggregation have been investigated. Four out of… CONTINUE READING