• Corpus ID: 40247573

[Influence of human mesenchymal stem cells on cell proliferation and chemo-sensitivity of K562 cells].

@article{Lin2006InfluenceOH,
  title={[Influence of human mesenchymal stem cells on cell proliferation and chemo-sensitivity of K562 cells].},
  author={Yu-mei Lin and Li-Mei Bu and Shao-juan Yang and Shen Gao and Gui-zhen Zhang},
  journal={Zhongguo shi yan xue ye xue za zhi},
  year={2006},
  volume={14 2},
  pages={
          308-12
        }
}
This study was aimed to compare K562 cell proliferation, chemo-sensitivity and alteration of MDR1 before and after adhesive culture with MSC, so as to evaluate the relationship between chemodrug-resistance of leukemia cells and hemopoietic microenvironment. K562 cell cultivated in suspension and adhesively cultivated with MSC were collected respectively and cell proliferation curves were drawn; the cell cycle was determined by flow cytometry; the effect of chemotherapy on cellular viability and… 
1 Citations

Influence of human bone marrow mesenchymal stem cells on proliferation of chronic myeloid leukemia cells.

TLDR
Co-culture of MSCs with CML could secrete a substantial amount of IFN-alpha, thus to inhibit the proliferation of CML cells, and assess the secretion of cytokines in the supernatant induced by M SCs.