• Corpus ID: 43612351

[Influence of different auxiliary materials on the dissolution of carbamazepine from solid dosage forms].

@article{Jekn1998InfluenceOD,
  title={[Influence of different auxiliary materials on the dissolution of carbamazepine from solid dosage forms].},
  author={B Z Jek{\"o}n{\'e}},
  journal={Acta pharmaceutica Hungarica},
  year={1998},
  volume={68 2},
  pages={
          133-6
        }
}
Results of the development of a solid dosage form containing 200 mg Carbamazepine (CBZ) are presented. Citric acid and low substituted Hydroxypropyl-cellulose (L-HPC) were used as dissolution enhancers of the active ingredient. Granulation the CBZ and citric acid with water has no effect on the dissolution of CBZ, but the granulation with absolute alcohol increases the dissolution rate. This enhancement could be explained with a molecular interaction between the CBZ and citric acid in water… 

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