[Induction of human platelet Ca2+ fluxes by anti-GP IIb/IIIa and anti-CD9 monoclonal antibodies].

  • Meng-Ge Wang
  • Published 1993 in
    Zhongguo yi xue ke xue yuan xue bao. Acta…

Abstract

Calcium plays a central role in platelet activation. Calcium changes in acquorin-loaded human platelets induced by monoclonal antibodies (McAbs) were recorded using a PIGA-apparatus. McAb Apt4 is specific for GP IIb/IIIa and McAb XW-1 and SJ-9A4 are directed against CD9 antigen. All three McAbs were shown to elicit a Ca2+ rise in aequorin-loaded platelets… (More)

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