[Induction of cytochrome P-450 and b5 of the mouse liver by phenytoin during chronic hypoxia (Fi02 : 0,08)].

@article{Bechtel1976InductionOC,
  title={[Induction of cytochrome P-450 and b5 of the mouse liver by phenytoin during chronic hypoxia (Fi02 : 0,08)].},
  author={Paul Bechtel and C Delafin and Y Bechtel},
  journal={Comptes rendus des seances de la Societe de biologie et de ses filiales},
  year={1976},
  volume={170 2},
  pages={325-30}
}
During chronic hypoxia at sea level (FiO2 : 0,08) the liver concentrations of cytochrome P 450 and b5 decreased. Phenytoin administration induces an increase in cytochrome P 450 and b5 liver content. The hydroxylation of phenytoin that was decreased at low level of cytochrome P 450 and oxygen, reached again a normal level after induction of cytochrome P 450 in spite of the persistency of a low level of available oxygen. Liver cytochrome P 450 concentration is the main limiting factor of… CONTINUE READING