• Medicine
  • Published in
    Gan to kagaku ryoho. Cancer…
    2005

[Induction of apoptosis in human head and neck cancer cell lines by an active component of OK-432 through p53-independent pathway via toll-like receptor (TLR) 4 signaling].

@article{Tano2005InductionOA,
  title={[Induction of apoptosis in human head and neck cancer cell lines by an active component of OK-432 through p53-independent pathway via toll-like receptor (TLR) 4 signaling].},
  author={Tomoyuki Tano and Masato Okamoto and Tetsuya Oshikawa and Sharif uddin Ahmed and Akiko Sasai and Mitsunobu Sato},
  journal={Gan to kagaku ryoho. Cancer & chemotherapy},
  year={2005},
  volume={32 11},
  pages={
          1562-4
        }
}
OK-PSA, an active component of OK-432, induces anti-tumor immunity via Toll-like receptor (TLR) 4/MD-2 complex. In the current study, we evaluated the effect of the OK-PSA on human head and neck cancer cell lines. Twelve cancer cell lines including 7 squamous cell carcinoma (SCC) cell lines and 5 salivary gland cancer (SGC) cell lines were examined. The quantitative real-time PCR analysis revealed that TLR4 mRNA was expressed in all 12 cell lines, and that MD-2 mRNA was expressed in 5 cell… CONTINUE READING