[Induction of HSP70 and neuronal damage following transient cerebral ischemia in rats].

@article{Nishi1993InductionOH,
  title={[Induction of HSP70 and neuronal damage following transient cerebral ischemia in rats].},
  author={Shinzo Nishi},
  journal={Nihon geka hokan. Archiv fur japanische Chirurgie},
  year={1993},
  volume={62 2},
  pages={71-81}
}
  • Shinzo Nishi
  • Published 1993 in Nihon geka hokan. Archiv fur japanische Chirurgie
Various studies have demonstrated increased synthesis of heat shock protein 70 (HSP70) in brain following transient ischemia, and a protective role for HSP70 against ischemic insult has been hypothesized. In this study, we determined the time course of HSP70 mRNA and HSP70 induction in rat hippocampus following ischemia using Pulsinelli's four-vessel occlusion model, and suggested a protective role for HSP70 induction in limiting ischemic damage to neurons and delayed neuronal death. In… CONTINUE READING