[Induction and prevention of kidney injury induced by GSH depletion and vitamin E deficiency in rats].

@article{Hagiwara1994InductionAP,
  title={[Induction and prevention of kidney injury induced by GSH depletion and vitamin E deficiency in rats].},
  author={Kiyokazu Hagiwara and Hisashi Ozasa and Kyoko Ota and Takashi Ichikawa},
  journal={Nihon Jinzo Gakkai shi},
  year={1994},
  volume={36 10},
  pages={1082-9}
}
Four-week-old Wistar male rats were fed a vitamin E (VE)-deficient diet for 8 weeks, followed by intraperitoneal injection of DL-buthionine- [S, R] -sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase, at the dose of 1 mmol/kg body weight. As we reported previously, GSH depletion by administration of BSO induced acute tubular necrosis in… CONTINUE READING