• Corpus ID: 26250107

[In vivo distribution and activation of 5-FU--with special reference to biochemical modulation of intracellular metabolism].

@article{Fujita1988InVD,
  title={[In vivo distribution and activation of 5-FU--with special reference to biochemical modulation of intracellular metabolism].},
  author={Hiroshi Fujita},
  journal={Gan to kagaku ryoho. Cancer \& chemotherapy},
  year={1988},
  volume={15 4 Pt 2-1},
  pages={
          996-1002
        }
}
  • H. Fujita
  • Published 1 April 1988
  • Biology, Chemistry
  • Gan to kagaku ryoho. Cancer & chemotherapy
5-FU is metabolized to FUTP and FdUMP in tumor cells and exhibits RNA- and DNA-directed cytotoxicity. Biochemical modulation of the intracellular metabolic pathways of 5-FU result in either selective enhancement of the antitumor effect or protection of the host. 1. Administration of pro-drugs of the active intermediates of 5-FU (FO-152, FF-705, TK-117, T-506) 2. Increase in PRPP level by inhibition of the de novo purine synthetic pathway, and greater production of cytotoxic 5-FU-containing…