[In vitro and in vivo biodegradation of sustained-release vehicle poloxamer 407 in situ gel].

Abstract

OBJECTIVE To observe the biodegradation of poloxamer 407 gel in acoustic capsule in vitro and in vivo, and to explore the applied perspective in the local drug delayed-release treatment for inner ear disorders. METHOD Weighing the remained amount of poloxamer 407 gel at 37 degrees C at fixation time interval. The right ears of 15 healthy guinea pigs as… (More)

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