Corpus ID: 23336885

[Importance of the components of the complex ester group for the action of acetylcholine and dicarboxylic acid dicholine esters].

@article{Beznosko1980ImportanceOT,
  title={[Importance of the components of the complex ester group for the action of acetylcholine and dicarboxylic acid dicholine esters].},
  author={B. K. Beznosko and V. A. Dobrina and D. Ioffe and O. I. Kolganova and N. I. Lukomskaia},
  journal={Farmakologiia i toksikologiia},
  year={1980},
  volume={43 1},
  pages={
          44-8
        }
}
  • B. K. Beznosko, V. A. Dobrina, +2 authors N. I. Lukomskaia
  • Published 1980
  • Medicine
  • Farmakologiia i toksikologiia
  • The substitution of ether oxygen by a methylene group in the acetylcholine molecule sharply decreases the muscarinic action, while the substitution of the carbonyl group by a methylene one reduces the nicotinic properties. Sebacoyldicholine possesses only nicotinic properties. The replacement of its ether oxygens by methylene groups lowers the stimulant action on the frog rectus abdominis muscle by two orders of magnitude, whereas the stimulant action on the cat sympathetic ganglion is 30-fold… CONTINUE READING