[Immunologic studies in thalassemia major].

  title={[Immunologic studies in thalassemia major].},
  author={Luisa Sen and M A Goicoa and P J Nualart and I J Ballart and Fernanda Palacios and Roberto Alejandro Diez and Marcel Estevez},
  volume={49 2},
It is accepted that the immune alterations in patients with thalassemia major (TM) are secondary to the continuous transfusion-related antigenic stimulation together with iron overload. We evaluated the immune status of TM patients and found quantitative alterations in the distribution of peripheral blood lymphocyte subpopulations as well as functional alterations in natural killer (NK) cytotoxicity, B-cell differentiation, T-cell immunoregulation and phagocyte functional activities. TM… CONTINUE READING